Tuesday, August 15, 2017

What is Rheumatology & arthritis ? Who is a Rheumatologist?

What is Rheumatology ?

Rheumatology is a field of medicine, which deals with diseases having joint pain, arthritis and other related symptoms. It derives its origin from word ‘rheumatism’, which means anything related to joint or body pain.
explaining what is rheumatology and arthritis
What is arthritis and Rheumatology? (Image courtesy -http://nyphotographic.com. Creative Commons 3 – CC BY-SA 3.0)

What is Arthritis ?

Arthritis means joint pain associated with inflammation (redness, warmth and swelling). All joint pains are not arthritis.
All joint pains are not arthritis.    
Most rheumatology diseases are a particular type of arthritis. However, depending on disease type, they can affect any organ of the body. Thus, they can be serious diseases too. They even affect children and young people.
Rheumatic diseases most commonly affect joints, but depending on type of disease they can affect any organ in the body.

Some common rheumatology diseases are :
  • Rheumatoid arthritis (RA)
  • Gout
  • Fibromyalgia
  • Ankylosing spondylitis
  • Reactive arthritis
  • Psoriatic arthritis
  • Systemic Lupus Erythematosus

Rheumatology diseases are autoimmune diseases

Rheumatic diseases are often autoimmune in nature. Autoimmune diseases are diseases,  where a part of one’s own immune system automatically starts  acting against itself. It is unknown why this ‘auto’ ‘immune’ activation causes problems only in a few. Note, it is not the low immunity, but over active immunity, which is the problem. Over active immunity loves to hit joints, this is why most rheumatic diseases have arthritis.
Rheumatic diseases have over active immunity causing problems to one’s own body. Joints are most commonly hit by this.

Who is a Rheumatologist ?
Rheumatologist is a physician doctor, who is specially trained to investigate & treat various types of arthritis and rheumatic diseases with medicines. They are also commonly known as ‘joint pain or arthritis’ doctors. They are different from orthopaedic doctors, who are surgeons. However, both type of doctors need to work together, at times, to treat some patients.
It is necessary to start treatment early if you suffer from rheumatic illness. As immunity is  over active in these diseases, the medicines used to treat these diseases regulate and sometimes suppress the immune system. Early effective treatment helps prevent serious joint damage and can help save life in serious rheumatic disease.

How to find practice mcq's for DM Rheumatology exams in India? Request

It provides packages for cracking MCQ’s of various super speciality exams in India with ability to give mock tests
First of its kind platform in India

How to prevent the nausea or sickness associated with methotrexate in rheumatoid arthritis ?

Methotrexate in Rheumatoid arthritis
Methotrexate is one of the most commonly used drug
because taking methotrexate is very important in RA. good, in arthritis. It is the most important drug for rheumatoid arthritis (RA). Methotrexate in most patients causes no side effects and is a very good drug. However, methotrexate can cause severe nausea or sickness, abdominal pain or even diarrhoea, in many patients. Many patients stop taking methotrexate due to this, which is not
There are very few drug options to treat RA, which are as low-cost and as good as methotrexate. Biologicals are next line drugs in such cases, they are very good drugs, but they are very costly and also increase the risk of infections.
For more information click below link

Why is there hypercoagulability in antiphospholipid syndrome and at the same time the patient has lupus anticoagulants that even elevate the PTT level? Request

Well it's a question that troubles even many doctors, coagulation is like maths for them. They became doctors as they never liked maths and ended up in biology :)
Being a Rheumatologist I deal with fare share of my APLA syndromes and this did puzzle me for a long time.
The main answer
Now basically lupus antocoagulant (LA) is some kind of antiphospholipid antibody. In vivo, that is in body, phospholipids are bound to endothelial cells on vascular surface. While in vitro, in aPTT test you add phospholipids to drive intrinsic pathway.
Basically in the body this LA or antiphopsholipid antibody can bind to phospholipids (PL) on endothelial surface cells.
Normally endothelial cells do not ‘expose’ their PL. (They maintain their dignity of good flow :)
Some primary damage might ‘expose’ this phospholipids. As a result, these antibodies or LA might bind to them, activate endothelial cells, leads to lot of cascade of reactions, which makes this cell hyperactive and initiates coagulation at cell surface.
Basically , LA requires some cell surface bound phospholipids to initiate coagulation.
What happens to LA in aPTT test then ?
The test is done in vitro in a tube (see above image..yes the yellow tube one). So basically you add blood, calcium, some contact factor which simulates endothelial surface and external phospholipids. There is no real endothelial cell surface bound PL’s in a in vitro aPTT test.
The intrinisic pathway of coagulation can proceed, which doesnt necessary requires cell surface phospholipids.
But, Lupus anticoagulant, binds to these phospholipids without a real endothelial cell. The phospholipids are consumed. There is no endothelial cell activation and coagulation by LA, as it happens in body. The intrinisc pathway of coagulation cannot proceed at normal rate due to lack of phospholipids and aPTT in tube gets prolonged.
How do you know its LA prolonging it and not factor VIII ?
  1. You add factor VIII or normal plasma with factor VIII if it corrects its factor VIII deficiency.
  2. You add lot of phospholipids - there is not enough LA to bind - free PL’s availaible for intrinsic pathway to go ahead, aPTT time corrects, becomes normal - you know its LA (voila :)
Hurray, you have got an answer. If you understood this much and otherwise happy with your life, go back relax and chill out. Spread this post. If you want to make you life more messy (as doctors normally do), read along.
Disclaimer :
No need to read below thing. I am just showing off my knowledge ;).
Don’t blame me if you got confused further :)
The problem is most medical people feel PT and aPTT test demonstrate what actually happens in body. In reality they don’t. In reality on tissue damage tissue factor is released, extrinisc pathway is initiated, initial thrombin formation later leads to amplification of coagulation by intrinisc pathway.
Now the way PT and apTT are designed, is to simulate only one pathway in vitro.
When you take a blood in tube and give lot of tissue factor, extrinsic pathway will dominate and hence you can detect any abnormalities in extrinisic pathway, this becomes PT test.
When you take blood in a tube with phospholipids, intrinsic pathway will dominate and hence you can detect abnormalities easily in intrinsic pathway, this becomes aPTT test.
Thus you simulate things to drive things on one road, extrinisc or intrinsic. In this way you can detect any roadblocks on either of them separately. In real life in body these pathways intersect. Extrinsic pathway starts and intrinisc pathway joins later.

In India, in which institutions are DM rheumatology seats available? Which kind of preparation is needed: the rheumatology subject specific or all 19 subjects like All India PG?

To the best of my knowledge the following are DM and DNB Rheumatology available in India (remember DM Clinical Immunology is same as DM Rheumatology, there is still no consensus on naming it immunology, rheumatology or both. You will get DM Rheumatology seats with a mix of this titles in India).

JIPMER 2 seats, one every 6 months
Separate entrance
(Rheumatology and Immunology based Mcqs – Kelley ‘ textbook on rheumatology, Harrison rheumatology and immunology section. Abbas textbook on immunology)
PGI ? 3 seats – 2 sponsored, 1 open
Separate entrance 
Based on medicine plus rheumatology (kelley’s textbook and Harrison)
All other NEET based (common medicine based exam)
Tamil nadu, MMC 3 seats Restricted to domiciles of TN ?
SGPGI – 4
IPGMER Calcutta -2,
NIIMS -3 (domiciles ?)
CMC Vellore 1-2 (1 might be sponsored)
DNB seats1) Hinduja Mumbai -1,
2) Gangaram delhi-1
3) Apollo delhi 1
4) Medanta 1-2 ?
5) Army hopsita delhi -1 (usually reserved)
As you can see mostly all seats will be filled by NEET which as we know ill be medicine based with common exam for all entrances.
If you want to specifically prepare for DM seats of JIPMER and PGI, you can subscribe to www.mymedtor.com, which has mcqs on rheumatology and immunology commonly asked in JIPMER and PGI exams.

Why doctors tend to be extra cautious and ‘over’ investigative? Request

I see that lot of patients and relatives complain about doctor’s tendency to do lot of unnecessary investigations.
Obviously, most people also feel that we tend to do same, just for financial gains.
The subsequent points explain how it’s most times in best interest of both doctors and patients. I also thought it will be cool and time saving to refer to a blog post, rather than argue with some layman/patient over it (which I am doing a lot these days :).
How do we define ‘excessive’ or ‘ over’ cautiousness / investigative nature ? What is really excessive?
The patient might say that anything that is not required is excessive. However, the answer is, it differs fora particular investigation etc. and the list can go on.from every situation. It will depend on too many factors, which doesn’t include all but, patient’s current symptoms, findings on clinical examination, response to previous treatment, patient’s financial condition, the answer we require
For example
If I am worried about cancer or life threatening situation, no investigation might seem excessive from doctor or patient’s perspective. But at the same time, I might not do a Vitamin D test in a patient with poor affordability and minor aches and pains.
2. The following is the argument which forms a basis for lot of criticism of some doctors: ‘When I went for a second opinion to another doctor, he said that I don’t require the test and I was fine with some medicines he gave. Why did the first doctor ask for it ?’. I can explain why this is a wrong way to interpret our decisions.
Firstly, all doctors have different level of competencies and comfort level.
For example
If a patient goes to a local family doctor for severe abdominal pain, he might think about appendicitis and ask for urgent abdominal sonography. However, if you go to a general surgeon who sees a lot many, he might be able to tell you that it is not appendicitis just by clinical examination alone.appendicitis
Secondly, the scenario totally changes when you are taking a ‘second opinion’. The doctor who is giving you a second opinion always has a distinct advantage over doctor who gave the first opinion.
Example
Suppose in the above example, patient of abdominal pain, the pain already might have been waning off, if wasn’t appendicitis. Thus, the second doctor is more confidently able to say it’s not appendicitis without a sonography.start got a few investigations before sonography and reached the 2nd doctor after some hours of
Most of times doctor was valid only for his competency, your condition at that time and his/her reasoning.first visit and things might have changed completely till then. The advice of first the second opinion visit is days after
Similarly, a patient might already tried doctor, but since you have failed that they have an advantage in knowing the same.first therapy. He/she might have given you the same drug/opinion as step / alternative he can move on to next obviously have had some treatment and failed it or not tolerated it. The second doctor has an advantage in knowing that and
3. ‘The unpredictability of medical science, fear of missing out something sinister and the fear of litigation’
Consider this real life scenario
A headache specialist who sees a lot of patients with headaches,, even if he feels 100 % that it is going to be normal.headache days later patient has a seizure (fit) and he is detected to have a brain tumour. The family sues the doctor. The doctor now does at least one CT scan and/or MRI in any patient with Few headache the patient thoroughly, he finds no need to do an MRI in him, feels its migraine and sends him home on some medications. sees and he long standing clinical examination. One day he gets a patient with good avoids unnecessary CT scan and MRI in most patients with
Now as heading suggests, there are many things which makes this doctor over cautious subsequently;
Despite his experience, the unpredictability of medical science unfortunately brought him a patient with no findings on examination and still having a brain tumour.
This instills MRI in each patient even his examination is normal.advice a fear in him/her of damaging the patient, his reputation and also possibly facing litigation, so he gets MRI in every headache patient because he doesn’t want to go through whole trauma gain. He/she will
The more experienced or more reputed the doctor, the more likely that he will investigate in detail so as to not miss out anything. This can get costly for patient unreasonable to criticise the doctor for keeping himself safe first.its, but
Sometimes a doctor has to investigate in detail as the clinical examination is not exactly forthcoming.
Most times both the doctor and patient feel relieved if relevant investigations are normal. Peace of mind for the patient requires him/her to bear the cost of investigations.
4. How does a patient/individual then consider his interest in such a scenario ?
Always get a good medical insurance, always have contingency plan for medical costs. If you want best and safest medical care, it is going to be costly for most of the above reasons.
The patients scan always discuss need the doctor for ordering the test.criticise choice with all pros and cons about doing or not doing the test. If the patient doesn’t decide to do the test, it’s his/her wish and if they get better without the test – it’s your luck, don a informed of a test with his/her doctor and can make
The high patient load and poor comprehensibility of Indian patients at times is if you feel you have asked a reasonable question and you haven’t got a satisfactory answer you can always change your doctor.However too unsuited for making reasonable medical decisions, hence doctor might order a test in you without giving much explanation.

Saturday, March 15, 2014

Thesis blues

Its a title which most of you doing your post graduate courses in medicine will identify it. I am facing it again in my DM (superspeciality) course. There are times when you start questioning the rationale of it (in fact it appears irrational most of the times). Though i side with those who believe that thesis should be integral part of one's postgraduate curriculum, more so in a superspeciality course, but the method in which we are made to do it in our country makes me go nuts. Most researches so done internationally involve logistic support, provision of manpower and funding. You cannot expect a post graduate student to carry out his ward/lab duties, study at the same time and carry out his thesis work all alone!! And that is why most thesis so submitted are poor in content and often with  forged data. Even a genuinely interested person will be bogged down by it, thesis completion rather becomes a forced upon baggage. It's time there is serious revision of how thesis projects are allotted and carried out. Unless there is provision of enough supporting manpower and funding the whole process of having a mandatory thesis should be scrapped. If not, there should be a provision so that many students can come together to do a single project rather than doing individual ones. That will go a long way in avoiding substandard and forged thesis whilst improving the publication potential of thesis so done in our country.